Role of liver in regulating distribution and excretion of manganese.

Role of liver in regulating distribution and excretion of manganese1p2

PAPAVASILIOU, P. S., S. T. MILLER, AND G. C. COTZIAS. Role of liver in regulating distribution and excretion of manganese. Am. J. Physiol. 2 I-I (I) : -2 I 1-2 16. I g66.-Rectal obstruction abolished the total-body loss of Mns4 in both manganese-loaded and jaundiced rats. Bile duct obstruction only diminished the excretion of the radioisotope, proving that several gastrointestinal routes excret...

Prevention of Nonalcoholic Steatohepatitis in Rats by Two Manganese-Salen Complexes

Background: Nonalcoholic steatohepatitis (NASH), a progressive stage of nonalcoholic fatty liver disease (NAFLD), is characterized by steatosis with inflammation. Investigations have suggested that oxidative stress may play an important role in the progress of NAFLD to NASH. To provide further insights into beneficial effects of antioxidants in NASH prevention, we employed two manganese-supero...

Matrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression

The proliferation of hepatocellular carcinoma (HCC) cells is one of the leading causes of liver cancer mortality in humans. The inhibiting effects of matrine on HCC cell proliferation have been studied, but the mechanism of that inhibition has not been fully elucidated. Since, apoptosis plays an important role in HCC cell proliferation. We examined the apoptosis-inducing effect of matrine on tu...

Short Communication:A comparative study on manganese accumulation in liver, kidney, fatty tissues including muscle of rainbow trout (Oncorhynchus mykiss) fed with different levels of manganese in the diet

Matrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression

The proliferation of hepatocellular carcinoma (HCC) cells is one of the leading causes of liver cancer mortality in humans. The inhibiting effects of matrine on HCC cell proliferation have been studied, but the mechanism of that inhibition has not been fully elucidated. Since, apoptosis plays an important role in HCC cell proliferation. We examined the apoptosis-inducing effect of matrine on tu...